What causes Alzheimer’s? Groundbreaking study reveals it may be something unexpected


The concentration of soluble amyloid-beta protein decreases when it turns into insoluble amyloid plaques due to various stress factor that affects its metabolism. The researchers point out that many clinical trials in the past that focused on treating Alzheimer’s, attempted to eliminate amyloid plaques in the human brain. However, none of those approaches except one have proved to be effective against the disease.

Interestingly, even the one trial that has been successful in providing relief against Alzheimer’s also uses a drug (lecanemab) that not only eliminates amyloid plaques but also increases the concentration of soluble amyloid-beta protein. Moreover, according to the researchers, the trials during which the level of amyloid-beta protein went down ended with negative results.

First author and neurologist at Karolinska Institute, Andrea Sturchio wrote, “I think this is probably the best proof that reducing the level of the soluble form of the protein can be toxic. When done, patients have gotten worse.”

The research is not just limited to Alzheimer’s disease

A suggestive image of neurons.

Sturchio and his team believe that if their hypothesis about Alzheimer’s turned out to be true then the same theory could also be considered for finding the root cause of various other degenerative brain disorders such as the Creutzfeldt-Jakob disease, Parkinson’s disease, etc. For instance, many studies suggest that Parkinson’s is caused due to accumulation of insoluble Lewy bodies in the brain.